Cannabinoider i fokus för nytt fetmaläkemedel

Segertåget för de nya fetmaläkemedlen av GLP-1-typ lockar allt fler att satsa inom området – men med andra metoder. Ett sådant bolag är Skye Bioscience, vars antikropp som är inriktad mot en cannabinoidreceptor nu ska prövas i fas II.

By Anders Göransson

August 23, 2024 11:06 AM

Tidigare forskning har visat att CB1-hämmare (cannabinoidreceptor1-hämmare) leder till viktminskning, men också till icke önskvärda neuropsykiatriska biverkningar, vilket gjort att projekten lagts åt sidan.

Men Kalifornienbaserade Skye Bioscience har modifierat sin monoklonala antikropp nimacimab så den ska bibehålla sin viktminskande effekt, men utan ovälkomna biverkningar på humöret, skriver Firstword Pharma.

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